Lines and Wrinkles
Protocol: Twenty subjects (ages 45-65 with at least
a score of 10 on the Packman Wrinkle Scale) used a test gel
with 3% Dermox twice a day over a four-week period on half of their
face. On the other half the base gel (a carbopol system) was used
in a similar fashion. At the start of the study and after four weeks
lines and wrinkles evaluated clinically via the Packman Method.
On ten subjects replicas were taken and an image analysis of lines
Results: As seen in Table 1 below, the use of Reventin
resulted in a 45.3% improvement in reducing lines and wrinkles over
a four-week test period using the Packman Method. This compares
to a 4.7% improvement with the base gel. The result is statistically
significant and represents a biologically meaningful improvement.
Results from image analysis
were similar with subjects showing a 56.4% improvement
compared to 3.2% for the control group (base gel). Representative
pictures are displayed
above(attachment 1) showing the treatment effects of Reventin.
Protocol: D-Squame tape strips, obtained from Cuderm
Corp., Dallas TX were used to assess the amount the desquamated
cellular material. Circular pieces of tape were firmly pressed to
the skin test site. After removal the degree of light scattering
was assessed with a Custom Photometer from Fermionics Electronics.
Less transmittance and more scattering was observed as the number
of cells on the tape increased. Twenty subjects applied test material
(3% Reventin) as above as squame analysis were made prior to the
first application of product and after five days of use were compared
with the control gel..
Results: As Table 2 shows after five days of treatment
a 84.7% increase in exfoliated cells was observed. This compares
with 7.3% for the control. Such an increase in exfoliation would
result in smoother skin and over time a significant increase in
cell renewal rates.